Is It Possible to Get High from Nutmeg? Here’s Why You Shouldn’t Try

Before thinking about using nutmeg as a recreational substance to achieve a “high,” it is important to recognize the serious health risks linked to myristicin toxicity, which can lead to organ failure or even death.

Nutmeg, scientifically known as Myristica fragrans, is a widely used spice valued for its warm aroma and slightly sweet flavor. Indonesia is one of the primary regions where this plant grows. The tree produces a fruit that contains the nutmeg seed, which is harvested and dried over several weeks before being processed into the familiar spice.

Nutmeg is commonly used in cooking, especially in:

• Desserts such as pies and puddings
• Savory meals and sauces
• Traditional beverages like eggnog

There have been claims that nutmeg can produce a “high.” While this is partially true, the full explanation involves important scientific details and potential dangers.

What is Myristicin?

The compound responsible for the psychoactive effects of nutmeg is called myristicin. This naturally occurring substance is found in the essential oils of several plants, including parsley, dill, and nutmeg, with nutmeg containing particularly high levels.

Once inside the human body, myristicin is metabolized into compounds that influence the nervous system, especially the sympathetic nervous system. Its effects can be compared to mescaline, a substance found in peyote, as both interact with the central nervous system (CNS) by increasing activity of the neurotransmitter norepinephrine.

This stimulation can lead to various symptoms such as dizziness, nausea, and even hallucinations.

Effects of Nutmeg Intoxication

Scientific research on nutmeg poisoning is limited, but available case reports highlight several harmful effects of excessive consumption.

Historical records of nutmeg intoxication date back to the 1500s. Modern case studies provide clearer insight:

• In one instance, an 18-year-old woman experienced nausea, dizziness, heart palpitations, and dry mouth after consuming about 50 grams of nutmeg in a drink.
• In another case, a 37-year-old woman developed confusion, drowsiness, and extreme dry mouth after ingesting only around 10 grams (roughly two teaspoons).

Symptoms in both cases appeared within a few hours and lasted up to 10 hours before recovery.

A 10-year review by the Illinois Poison Center documented more than 30 cases of nutmeg poisoning. About half were intentional, while others occurred accidentally—especially among children under 13.

Common symptoms reported include:

• Hallucinations
• Drowsiness
• Dizziness
• Dry mouth
• Confusion
• Seizures (in rare cases)

Additional complications can involve the respiratory, cardiovascular, and digestive systems.

Risks of Nutmeg Overdose

Although nutmeg is a common kitchen ingredient, consuming it in large amounts can be dangerous due to the potency of myristicin.

Beyond short-term symptoms, severe toxicity can result in organ failure or even death, particularly when combined with other substances. Research indicates that doses as low as 10 grams may already produce toxic effects, while 50 grams or more can significantly increase the risk.

In contrast, normal culinary use is safe. Most recipes require only about 1/4 to 1/2 teaspoon, which is typically divided across multiple servings, making exposure minimal.

The method of consumption also plays a role in how quickly the substance affects the body. While ingesting nutmeg orally is the slowest method, alternative methods such as inhalation or injection can accelerate its impact—though these practices are especially dangerous and strongly discouraged.

Conclusion

Like many substances with psychoactive potential, the risks of using nutmeg recreationally far outweigh any perceived benefits. Myristicin toxicity can lead to serious and potentially life-threatening consequences.

However, when used in small amounts for cooking, nutmeg remains safe and enjoyable. The key is moderation—allowing you to appreciate its flavor without exposing yourself to unnecessary health risks.